Low Dose Naltrexone (LDN) Provides Surprising Pain Relief (News)

Low Dose Naltrexone (LDN) Provides Surprising Pain Relief

The People's Pharmacy
18 August 2022

People who suffer with severe chronic pain often face a difficult dilemma. Opioids aren’t considered appropriate for long-term use. Physicians and pharmacists may be chastised by their professional organizations if they repeatedly prescribe or dispense such drugs. NSAIDs like diclofenac, ibuprofen, meloxicam or naproxen can lead to dangerous side effects including bleeding stomach ulcers, high blood pressure and heart attacks. As a result, finding a way to manage chronic pain can be quite a challenge.

There is some reason to believe that at low doses, naltrexone helps regulate the immune system. Low dose naltrexone (LDN) is being investigated for its ability to relieve the pain of fibromyalgia, Crohn’s disease, multiple sclerosis, chronic fatigue syndrome and ALS aka Lou Gehrig’s disease, and a number of auto-immune conditions as well as chronic pain.  

The FDA has never approved LDN for treating pain or inflammation. And because naltrexone is no longer under patent, no drug company is likely to spend money to see if it could be repurposed for other conditions.

Most people tolerate LDN well, although some report nausea, nightmares or vivid dreams. Taking it in the morning may reduce sleep disturbances.