Low Dose Naltrexone (LDN) transdermal route?

LDN Q&A Webinar Feb 2022

Low Dose Naltrexone (LDN) transdermal route?

The next question is, in the Netherlands there is Low Dose Naltrexone (LDN) cream. What is the indication to use the transdermal route? This is from a gynecologist in the Netherlands, and in fairness, in the UK we have almost no experience of LDN in gynecology. Does anybody else have any experience?

Oh yeah, we use it for lichen sclerosus topically with LDN, and I would say we've had some success. It takes awhile. It's like six months. You really have to give it time to work. But we have seen results using it in lichen sclerosus and then as far as well that would be a transdermal route. I guess anything else, Michelle, that you can think of?

Well, you know when we're treating gynecological issues, that's a topical route, whereas transdermal we would use maybe for autism, because that's actually gonna drive it through the skin. So yes, we we do see it used especially for lichen, and even if there's some other inflammatory issues going on, we can definitely use low dose naltrexone, and then depending on the base that we put it in, we can actually use some muco-adherent types of bases to help the medication stick there, so you don't have to use a lot, 0.5 milligram per gram. You just don't need a lot, which is really really nice, and that's going to help not only with the irritation, but also help to reduce the autoimmune issues

Answered by LDN Specialist Pharmacists Stephen Dickson, Dr Sam Lebsock and Michelle Moser