Is Low Dose Naltrexone (LDN) Useful for Treating Vitiligo?

Is Low Dose Naltrexone (LDN) Useful for Treating Vitiligo?

What about vitiligo and LDN?  That is a great question.  The answer is yes.  Vitiligo is a great example of an autoimmune disease. There are several cases that I've heard of.  I've not actually seen one myself where the LDN did make a difference for the vitiligo patient.  There are a number of topical treatments that are being done for vitiligo; combinations of tacrolimus, there's data out there on five fluorouracil.  We've got formulations with five fluorouracil that are used in conjunction with micro needling I should say.  Same thing with tacrolimus in conjunction with micro needling and then oral Low Dose Naltrexone would be an adjunct to that.  I would add that on to the topical treatments as well.  Certainly the biologics are being used to treat vitiligo as well but there's some data out there on topical latanoprost for vitiligo. Those are the newer, latest and greatest topical things that people are doing.  There was an older formula for a pseudo catalase product that was affecting production of peroxide which was leading to the damage of the melanocytes long term from the peroxide. It was a hit or miss whether that was helpful or not for the patients.  I would rather see the patient try to focus more on the immune side of things, so definitely LDN should be used.