Is Low Dose Naltrexone (LDN) Useful for Weaning off Benzodiazepines? 

LDN Specialist Pharmacist Michelle Moser
Pharmacist Michelle Moser

Is Low Dose Naltrexone (LDN) Useful for Weaning off Benzodiazepines? 

The question was asked if there are resources for those who take Low Dose Naltrexone (LDN) and that are titrating off benzodiazepine and if there is a connection between GABA receptors and opioid receptors and endorphins.   LDN has worked very well in addiction situations, whether alcohol, opiates, or smoking.  Addictive properties are very similar no matter what it is you're addicted to. There can also be some micronutrient deficiencies associated with certain benzodiazepines and not others.  If so, we have to supplement those pathways.  That’s where the GABA receptors connect with the opiate receptors and the endorphins.  It is because the body is a whole body, not just specific areas, not just pieces.  There's a connection between GABA receptors, opiate receptors and endorphin receptors.  

Whether you're dealing with the endocrine system or other neurotransmitter receptors, think of the five Olympic rings; three on top and two on the bottom.  There are five different colors and through one touches the other, and circles around, there's space between them and there is a little bit of overlap so there is connectivity between those.  Whether it's the brain centrally in the body cavity or the gut because you have opiate receptors.  You have the release of endorphins and GABA receptors in a lot of different places.  

LDN can literally help tremors associated with addiction and getting off of your addictive drug.  It can also help to feel important emotions, which is why LDN is used in mental health a lot.  Benzodiazepines can help  sleep or to numb some issues in life to help you get through the process.  

When taking LDN you can also use GABA, L-theanine or other supplements to help regulate the HPA axis such as ashwagandha, holy basil, or magnolia. Make sure you have a functional provider to assist you.