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Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series
J Am Acad Dermatol
August 2019
https://pubmed.ncbi.nlm.nih.gov/31002846/
Low-dose naltrexone (LDN) was assessed in a large series of patients with Hailey-Hailey disease (HHD). The LDN was administered to patients with biopsy-proven, refractory HHD. The LDN started off with doses of 1.5-6 mg/d. Incremental doses were indicated depending on the clinical response of each patient. The highest doses of LDN that was given were between 25 or 50 mg/d, due to unresponsiveness of the patient. The study included 14 patients between the ages of 52-68 years. This study observed a lack of response or initial response with several relapses in most patients.
Keywords: Hailey-Hailey disease, low dose naltrexone, LDN, biopsy proven, relapse
Summary and Keywords by Erin Williams, student, St. Louis College of Pharmacy