Need for Low Dose Naltrexone (LDN) Clinical Trials and Studies

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LDN Specialist Pharmacist Michelle Moser
LDN Specialist Pharmacist Michelle Moser

Need for Low Dose Naltrexone (LDN) Clinical Trials and Studies

This question is literally a question that I field many times a week, and I’m sure you all do as well: is there is a great need for well-controlled studies on the use of LDN for disease states, or various symptoms, rather than relying on very small studies and just anecdotal reports on Low Dose Naltrexone (LDN)?

What I try to refer to is, first of all, there are well over 900-950 studies. including approximately 20 to 30 that have been conducted even in the last three or four years; but there are well over 900 studies on the use of low dose naltrexone in a wide variety of situations. My most favorite document that I hand out to providers, I refer to as the Dartmouth study. It literally is a summary of over 900 articles based on the conditions in which they were studied and the results, including the dosing and the patient population that was used, the numbers etc. That is my favorite because it's a very nice, succinctly packaged summary of how LDN is used. So I've been a pharmacist for 35 years, and quite honestly, I have yet to find pretty much any other commercially available medication that has got over 900 papers written on it, with the exception of maybe the coronavirus vaccine. I think LDN is incredibly well studied, and has been used not only in US population, but populations across the globe, very well. And what we consistently find is that the mechanisms of action are very succinctly described. Because most diseases are inflammatory in nature, that's why it's applicable to so many different situations across the globe. But I would say that there are some great case studies, but again those are case studies, but there are also some very good scientific studies out there. We are happy to provide those, Linda. I'm not sure if the Dartmouth study is available on the website. I haven't looked for it quite honestly, but it's it is available in PubMed. I have it right behind me on the shelf but the specific authors’ names escape me at the moment.

Linda Elsegood: All the research papers that we can find as they come along, we add them to the website, and we put them under Conditions as well so they should be easily found