Neuropathic Pain and Low Dose Naltrexone (LDN). So, the next question then is, "Neuropathic pain?" Neuropathic pain - absolutely LDN. If you've tried everything else, there is absolutely no reason not to try Low Dose Naltrexone (LDN), and in fact there are lots of presentations on the LDN Research Trust website, especially by Dr. Chopra, about chronic regional pain syndrome, which is one of the most difficult types of neuropathy to treat. And it does seem to be very effective, and in the US right now, low-dose naltrexone is in phase two trials regarding chronic regional pain syndrome. So there's that as well. Answered by LDN Specialist Pharmacist Stephen Dickson