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Naltrexone is an FDA approved ingredient of a fat loss prescription medication Contrave (bupropion-naltrexone,a prescription-only diet product). Naltrexone is an opioid receptor blocker. Opioid receptors are generally regarded as a factor in the neuro-chemical routes that decide pleasure, reward, and behavior development. Naltrexone on its own is not approved for losing weight fast, and this is an off-label use of the drug. The naltrexone-bupropion combination, if used together with life style involvement and moderate calorie reduction appears to be quite successful for 6-month and 1-year results for clinically decent weight loss (over 5% of total body weight).