Plasma beta-endorphin levels, naltrexone, and haloperidol in autistic children (Abstract)

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Plasma beta-endorphin levels, naltrexone, and haloperidol in autistic children

Psychopharmacol Bull
1993
https://pubmed.ncbi.nlm.nih.gov/8290669/

Plasma beta-endorphin levels were measured in 13 autistic children, aged 3.67 to 11.67 years at the end of treatment (naltrexone, haloperidol, pimozide, or placebo) and in 5 of the 13 children also at baseline. Baseline plasma beta-endorphin levels were lower than those reported in the literature. There was a strong correlation between plasma beta-endorphin levels and severity of sterotypies in all children. Naltrexone did not seem to have a specific effect on plasma beta-endorphin levels; short-term haloperidol treatment was associated with an increase, whereas long-term haloperidol treatment seemed to have a depressive effect on plasma beta-endorphin levels, which rose after withdrawal of haloperidol.