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Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone (Abstract)
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone
J Clin Aesthet Dermatol
Hailey-Hailey (HHD), or benign familial chronic pemphigus disease, is a rare autosomal dominant blistering disorder characterized by recurrent vesicles that erode and macerate into weeping and crusting plaques. HHD has been shown to be resistant to several treatment options. Although not yet approved as a treatment for HHD, recent reports have suggested the use of low-dose naltrexone (LDN) as a successful treatment option for controlling recalcitrant HHD. We present a case of a 50-year-old woman with a 20-year history of biopsy-conﬁrmed HHD with recurrent painful and pruritic vesicles and plaques. The patient developed signiﬁcant clinical improvement of the cutaneous lesions with LDN treatment after only 26 days of treatment. It is important for dermatologists to consider LDN as a viable treatment option for HHD, especially in recalcitrant patients. We suggest this novel treatment as a rapidly eﬀective option to resistant HHD.
KEY WORDS: Hailey-Hailey disease, recalcitrant Hailey-Hailey disease, low-dose naltrexone, benign familial chronic pemphigus disease, blistering disorders