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Our 2020 guides will be updated it was generally thought to be non-compatible but now is being used with caution in conjunction with biologic agents with success (such as Humira and Enbrel). In fact, I have several patients in my practice achieve greater success in mitigating their autoimmune condition utilizing the synergistic action of LDN + Biologic agents, and I have also had several patients wean off of their biologic agent and continue LDN.