Research suggests toll-like receptor 4 appears to play role in severe COVID
Medical Research News
16 August 2021
The authors of the current study reported that the SARS-CoV-2 spike S1 subunit not only binds and activates TLR4, but also upregulates ACE2 expression in rat cTMFs. Significantly, this work presents evidence for the further development of TLR4 antagonist drugs to improve the treatment of COVID-19 by reducing viral entry and inflammation.