Severe pruritus of cholestasis in disseminated cancer... (Abstract)

The LDN 2021 Conference Recordings Now Available with up to 29 CME Credits [More Details]

Medical Professionals Become an LDN Specialist [More Details]

Severe pruritus of cholestasis in disseminated cancer: developing a rational treatment strategy. A case report

J Pain Symptom Manage
January 2005
https://www.sciencedirect.com/science/article/pii/S0885392404003914

Severe pruritus is a frequent complication of cholestasis. Both serotonin and opioids play an important role in the development of this symptom. Guidelines to provide rational management of pruritus of cholestasis do not exist. We describe a patient with complex and malignant course of pruritus. She responded to several measures proposed (among other naltrexone), but rapily became tolerant to them. Buprenorphine with an ultra low dose of naloxone was able to control her symptoms without development of tolerance until her death.

Pruritus, itch, cholestasis, naltrexone, buprenorphine