Is there a way to increase your LDN dose while avoiding major GI issues, diarrhoea and increased anxiety? How can this all be mitigated and issues caused by fillers? 

Is there a way to increase your LDN dose while avoiding major GI issues, diarrhoea and increased anxiety? How can this all be mitigated and issues caused by fillers? 

So in some patients when they take LDN orally, they have issues with their GI and that can be because, in a similar way to when you have diarrhoea, you would take what's basically an opiate medication, Imodium or Loperamide, and that slows down gastric motility. 

Now, in people with chronic issues, or who are over expressing opiate receptors in their gut, when you take LDN, you can have the opposite effect because you're basically removing the inhibition for, the natural effects from endorphins, for the gastric motility. So in that particular case, we’d probably suggest moving the patient to a sublingual preparation rather than an oral preparation or indeed introducing gastric motility assisting agents, something like fybogel during a period of time, or increasing the dose so that they can get to actual dose and let those opioid receptors internalize or reduce or normalize so that those symptoms aren't in present. 

Now increased anxiety is a sign that you are very sensitive to the ingredients in the actual naltrexone itself because the release of the endorphins, in certain people, can cause a feeling of agitation or anxiety as described. And if that's the case what you would really do in most people is you would half the dose and go up again very, very slowly in 0.5 mg over every week or every two weeks. And if you cannot get past 1.5 to 2 mg, you know, and without developing those symptoms, drop back down to the highest dose that you can take where those symptoms are not present. and no, that’s not fillers, there are not enough fillers in those preparations to cause those effects.