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This video by Dr. Sarah Zielsdorf, MD, MS explores the complex concept of inflammation within the immune system, drawing an analogy to a historical fire brigade. It details how signaling molecules, like cytokines, can either escalate or quell inflammatory responses. The discussion then shifts to Low-Dose Naltrexone (LDN) and its potential role in modulating these processes, highlighting its mechanism of action on opioid receptors and its impact on endorphins and microglia.
Dr. Sarah Zielsdorf, MD, MS: This shows a synergistic relationship just like in our systems in our immune systems we have cytoines which are pro and inflam anti-inflammatory pathways um which signal and there are many different intermediates. So we have to use a variety of tools to quench this fire and I think of LDN as the bucket brigade.
So naltrexone is dosed at 50 to 200 mg uh by FDA approval. It was approved in 1984 for the treatment of opiate addiction and in 1995 for alcohol abuse. Dr. Dr. Bernard Bhari was a New York neurologist and he was the physician that used initial um off label use of Nrexone in doses ranging from 1 and a half milligram to three and then 4 1/2 milligram as an adjunct therapy for HIV AIDS in the 1980s they had the realization that endorphins are critical for an appropriate immune system response and then there's Dr. Dr. Ian Saigon and his work on MET and Kephilins or opioid derived growth factor and opioid derived growth factor receptor.
Low dose Naltrexone is a non- selective antagonist. It has strong effects on the muopioid receptor and delta opioid receptor but less antagonism of cappa opioid receptors. And these are the roles of LDN. You can see improve menilins and betaendorphine synthesis. Modulate microg ga which are like the trash cans in the central nervous system which eat up pathogens. Modulate the immune system and support it for being better and more able to fight off infections. It's anti-inflammatory and so much more.
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