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Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review
Sarcoidosis Vasc Diffuse Lung Dis
10 Aug 2020
https://pubmed.ncbi.nlm.nih.gov/32776297/
Purpose: To report a case of vulvar familial benign pemphigus, or Hailey-Hailey disease, treated successfully with low-dose naltrexone and to review the current literature.
Methods: We report a case of a 71-year-old white woman with vulvar Hailey-Hailey disease recalcitrant to topical corticosteroids. After treatment with low-dose naltrexone, 3 mg nightly was initiated, the lesions began to heal and 5 months later her skin showed no lesions. A literature review on the use of low-dose naltrexone for Hailey-Hailey disease was performed. We searched the PubMed/MEDLINE databases for previous case reports using the key words ''Pemphigus, Benign Familial'' and ''naltrexone".
Results: We found 35 more cases of Hailey-Hailey disease treated with naltrexone, showing promising results, reported until January 2020, with no major adverse effects.
Conclusion: Low-dose naltrexone may represent a cost-effective and successful treatment modality in nongeneralized Hailey-Hailey disease without serious adverse effects. Future prospective studies are needed to investigate this interesting therapeutic option.
Keywords: Familial benign pemphigus; Hailey–Hailey disease; Naltrexone; Vulvar disease.