About Hailey Hailey disease, which mechanism can explain LDN efficacy? Hailey Hailey is an autoimmune disease. The question is, what can explain the efficacy of LDN for Hailey Hailey disease? It is an autoimmune response. Hailey Haley disease is a genetic disease of course, and I think the immune response, the anti-inflammatory plays a role but I think it more it has to do with the immune system at that point and it might be more to deal with the auto inflammation in that particular case. In either case it's going to be beneficial.