What is the highest dose to still be called low-dose naltrexone?
Well, I think that there's probably a little bit of debate about that, but I think any time you get over 6.0 milligrams thereabouts. I think Dr Paul Anderson talked about that at the 2021 LDN Research Trust Conference. He is using doses, and there's a few other providers as well that are using doses a little bit higher than 4.5, but I think once you start getting into double digits, then you're not really dealing with low-dose naltrexone, and I think that that was shown even way back in Dr Bihari's time back in 1985 when he was doing some research, that specifically looking at 25 milligrams or even 12.5 milligrams, that the mechanism of action started changing. So the lower we got, we got into better, and in different mechanisms to really work with not only an endorphin system, but specifically to help reduce inflammation through the cytokines and tolerance receptors.
Michelle Moser, RPh, FACA, FACVP