What drug was used to get MCAS patients off of H1, H2 and Prednisone? 

What drug was used to get MCAS patients off of H1, H2 and Prednisone? 

Let me just spell it's A-M-L-E-X-A-N-O-X: Amlexanox. It acts on different mechanisms. Antihistamine and inflammatory. Used topically in the United States for Aphthous ulcers, but used heavily in Japan for a lot of Allergy conditions, Asthma, Anaphylaxis etc. I've taken it myself. Very low side effect profile. A little bit costly to compound. 

I start folks out at 40 milligrams once daily, and then you can go TID on that, depending on your response. It's made in commercial labs in Japan, It’s made in 25 and 50-milligram tablets, but it's not available in the United States. 

If you have your favorite compounders, get them to stock it for you. I had to push one compounder to stock it because they said, ‘well, we need ten prescriptions’. I said, ‘I have five in the wings that are waiting for this stuff’. They finally capitulated and they stocked it up, now they can't keep it on the shelf. So just talk to your friendly compounder and they’ll get it for you. It's commercially available from some sources.