At which point would I titrate up on Low Dose Naltrexone (LDN)?

LDN Specialist Pharmacist Michelle Moser
Pharmacist, Michelle Moser 

At which point would I titrate up on Low Dose Naltrexone (LDN)?

I am hypersensitive to most medications. My doctor has prescribed 0.5 LDN once a day. Does this seem appropriate and at which point would I titrate up? 

That's a very good question. So I'm assuming a 0.5 means milligrams. So sometimes people are confusing milli-grams with the volume that they're using in liquids, for example. So when people are hypersensitive to most medications, that means that there's a lot of inflammation going on in the body. 
There's some disruption in their gut, food sensitivities as well. And because most commercial medications, whether they're over-the-counter or prescription, are packed in lactose, different fillers, as well as colorants, sometimes that's what we're very sensitive to. 

So you can and have your Low Dose Naltrexone capsule or tablet compounded by a very good compounding pharmacy that can help you with a different filler as well. So speaking of fillers, when we're talking about some of the common questions that are coming up, especially on Facebook, we see a lot of information about fillers and how people should just absolutely stay away from Avicel or Microcrystalline Cellulose. 
And I don't agree with that. I don't agree with that at all. I don't like to make blanket statements when it comes to a yes filler, a no filler. Because it really is about you and how you are going to react with that. 

So for non-medical people telling people to stay away from this, that, or the other thing, I don’t like that because there's so much that goes into decision making when we're looking at fillers. 

So some people do very, very well. I will say the majority of people do very well on microcrystalline cellulose, because it is considered inert. And because all the proteins have been removed, and it's a very highly purified product. And it is a small particle size, so it's very easy to compound with. 
There's a wide variety of other fillers that we can use as well. When we're using a 0.5 milligram capsule or tablet, we absolutely have to use fillers. 
There's no way that we can measure 0.5 milligram, put it in a capsule or a tablet all by itself. It's just, it's like half a spec. There is just no way to do that. 

Most people will titrate up about every seven to 14 days. Again, if you are hypersensitive, start low, and go slow. Keep track of your symptoms. And if you get to a point where you increase your dose and you don't feel as good as what you did last week on that previous dose, go back down. That's quite all right.