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Will Low Dose Naltrexone (LDN) make hormonal migraines worse?
If a patient experiences hormonal migraines, will taking LDN make migraines worse? Or is it just patient-dependent and a case of trial and error?
A lot of people find if they are prone to having migraines once they start on LDN, because it reduces neuroinflammation and because it has an effect on nitrous oxide production, there's various reasons why it may help some people with migraines, but it may also worsen some other people's migraines. So again, it's trial and error.
In the majority of cases, if people develop migraines after starting LDN and it can be managed by changing the dose or changing the time of day that they take it. If they have chronic migraines, generally coming from a place of neuroinflammation, you can look at using LDN to reduce that.