Clinical Trials

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis

Condition: Psoriasis, Skin

Intermittent blockade of OGFr and treatment of autoimmune disorders

Condition: Autoimmune, Fatigue, Fibromyalgia, MS, Multiple Sclerosis

The Uses of Naltrexone in Dermatological Conditions

Condition: Hailey Hailey, Hailey-Hailey, Lichen, Pruritus, Psoriasis, Scleroderma, Skin

Clinical utility of the cold pressor test: evaluation of pain patients, treatment of opioid-induced hyperalgesia and fibromyalgia with low dose naltrexone

Condition: Fibromyalgia, Opiod, Pain

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review

Condition: Dermatitis, Hailey Hailey, Hailey-Hailey, Lichen, Pruritus, Skin

The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma

Condition: Breast, Cancer, Carcinoma

Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization

Condition: Cancer, Carcinoma, Complex Regional Pain Syndrome, Crohn’s, Fibromyalgia, Hailey Hailey, Hailey-Hailey, MS, Multiple Sclerosis, Opiod, Pain, Ultra low dose naltrexone

Naltrexone and nalmefene attenuate cocaine place preference in male mice

Condition: Substance Use

Pharmacokinetic and pharmaceutical properties of a novel buprenorphine/naloxone sublingual tablet for opioid substitution therapy versus conventional buprenorphine/naloxone sublingual tablet in healthy volunteers.

Condition: Opiod

Successful treatment of dermatomyositis with low-dose naltrexone

Condition: Dermatomyositis, Skin

Treatment of psoriasis vulgaris using low-dose naltrexone

Condition: Psoriasis, Skin

Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis: A Case Report

Condition: Autoimmune, Psoriasis, Skin

Generalized familial benign chronic pemphigus (Hailey-Hailey disease) treated successfully with low-dose naltrexone

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus, Skin

Low Dose Naltrexone and Lung Cancer: A Case Report and Discussion

Condition: Autoimmune, Cancer, Carcinoma, Crohn’s, HIV, MS, Multiple Sclerosis

Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats

Condition: General, Medications

Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy

Condition: Autoimmune, Cancer, Carcinoma, Crohn’s, Immune, MS, Multiple Sclerosis

Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial

Condition: Opiod, Substance Use

The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia

Condition: Autoimmune, Depression, Fatigue, Fibromyalgia, Mental Health, Pain

Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care

Condition: Cancer, Carcinoma, Colon, Opiod

Double-blinded placebo-controlled cross-over pilot trial of naltrexone to treat Gulf War Illness

Condition: Depression, Fatigue, Gulf War Illness, Mental Health, Pain

Morphine reduced perceived anger from neutral and implicit emotional expressions

Condition: Autism, Opiod, Post Traumatic Stress, PTSD

The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study

Condition: Crohn’s, IBD, Inflammatory Bowel Disease, Ulcerative Colitis

Low dose naltrexone for induction of remission in Crohn's disease

Condition: Crohn’s, IBD, IBS, Inflammatory Bowel Disease, Irritable Bowel Syndrome

The Uses of Low-Dose Naltrexone in Clinical Practice

Condition: AIDS, Arthritis, Autoimmune, Cancer, Carcinoma, Crohn’s, Depression, Dissociative, Fatigue, Fibromyalgia, HIV, HIV/AIDS, Immune, Mental Health, MS, Multiple Sclerosis, Opiod, Pain, Post Traumatic Stress, PTSD, Rheumatoid, Rheumatoid arthritis

Low dose Naltrexone for induction of remission in inflammatory bowel disease patients

Condition: Crohn’s, IBD, IBS, Inflammatory Bowel Disease, Irritable Bowel Syndrome

Variable Response to Naltrexone in Patients With Hailey-Hailey Disease

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus, Skin

Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users: A Preliminary Laboratory Study

Condition: Alcohol, Smoking, Substance Use

Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis

Condition: Autoimmune, Encephalopathy, MS, Multiple Sclerosis, Opiod

The safety and efficacy of low-dose naltrexone in the management of chronic pain and inflammation in multiple sclerosis, fibromyalgia, Crohn's disease, and other chronic pain disorders

Condition: Crohn’s, Fibromyalgia, MS, Multiple Sclerosis, Pain

Emerging Unconventional Therapies for Alopecia Areata

Condition: Alopecia, Autoimmune, Skin

Featured Article: Modulation of the OGF–OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis

Condition: Encephalopathy, MS, Multiple Sclerosis

Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment

Condition: Autoimmune, Mast Cell Activation Syndrome, MCAS, POTS, SIBO, Small Intestinal Bacterial Overgrowth

Low-dose naltrexone for the treatment of sarcoidosis

Condition: Sarcoid

Co-administration of low-dose naltrexone and bupropion reduces alcohol drinking in alcohol-preferring (P) rats

Condition: Alcohol

The Long-Term Survival of a Patient With Stage IV Renal Cell Carcinoma Following an Integrative Treatment Approach Including the Intravenous α-Lipoic Acid/Low-Dose Naltrexone Protocol

Condition: Cancer, Carcinoma, Kidney, Renal

Neuropathic Corneal Pain: Approaches for Management

Condition: Eye, Neuropathy, Pain

Psychoneuroimmunological approach to gastrointestinal related pain

Condition: Crohn’s, IBD, IBS, Inflammatory Bowel Disease, Irritable Bowel Syndrome

Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis

Condition: Fatigue, MS, Multiple Sclerosis, Opiod

Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris

Condition: Lichen, Skin

Ethical Considerations of Patient-Funded Research for Multiple Sclerosis Therapeutics.

Condition: MS, Multiple Sclerosis

Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study

Condition: MS, Multiple Sclerosis

Combination therapy for obesity

Condition: Obesity