Clinical Trials

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study

Condition: IBD, Inflammatory Bowel Disease

Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents alcohol relapse-like drinking in male and female mice

Condition: Alcohol, Substance Use

Low-Dose Naltrexone-Induced Remission in Hailey-Hailey Disease Maintained in Remission with Topical Combination of Ketamine and Diphenhydramine

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus, Skin

Low-dose naltrexone: a novel adjunctive treatment in symptomatic alopecias?

Condition: Alopecia

Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus, Skin

Opioid antagonists as potential therapeutics for ischemic stroke

Condition: Opiod, Stroke

Hailey-Hailey disease treated successfully with naltrexone and magnesium

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus, Skin

Low-dose Naltrexone Therapy in Benign Chronic Pemphigus (Hailey-Hailey Disease): A Case Series

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus

Naltrexone for the Treatment of Darier and Hailey-Hailey Diseases

Condition: Darier, Hailey Hailey, Hailey-Hailey, Pemphigus, Skin

Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy

Condition: Cancer, Opiod, Pain

Low Dose Naltrexone Easing Pain from Fibromyalgia and Other Painful Conditions

Condition: Fatigue, Fibromyalgia, Pain, Rheumatoid

Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis

Condition: Connective Tissue Disease, Dermatomyositis, Fatigue, Pruritus

Sjogren's Syndrome: Clinical Benefits of Low-dose Naltrexone Therapy

Condition: Autoimmune, Dry Eye, Fatigue, Pain, Rheumatoid, Sjogren's Syndrome

Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice

Condition: Alcohol, Substance Use

Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts

Condition: Osteoporosis

Use of low-dose naltrexone in the treatment of severe Hailey-Hailey disease: One case report

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus, Skin

Low Dose Naltrexone for Neuropathic Pain Related to an Electrical Burn Injury: A Case Study

Condition: Neuropathy, Pain

Low-Dose Naltrexone in the Treatment of Fibromyalgia: A Retrospective Analysis

Condition: Fibromyalgia, Pain

Low Dose Naltrexone: A Viable Alternative for Long Term Chronic Pain?

Condition: Pain

Low Dose Naltrexone in Dermatology

Condition: Cancer, Charcot Marie Tooth, Charcot-Marie-Tooth, Crohn’s, Depression, Fibromyalgia, Pain, Scleroderma, Skin

Proceedings #47: Low Dose Naltrexone: A Viable Alternative for Long Term Chronic Pain?

Condition: Opiod, Pain

Inexpensive compounding of low dose naltrexone (LDN) with orange juice

Condition: Dermatomyositis, Hailey Hailey, Hailey-Hailey, Lichen, Psoriasis

Combination of clinically utilized kappa opioid receptor agonist nalfurafine with low-dose naltrexone reduces excessive alcohol drinking in male and female mice

Condition: Alcohol

Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes

Condition: Pain

Disease remission after commencing naltrexone in an atypical case of Crohn’s disease complicated by recurrent Clostridium difficile infection

Condition: Crohn’s

The use of naltrexone in dermatology. Current evidence and future directions

Condition: Alopecia, Dermatomyositis, Hailey Hailey, Hailey-Hailey, Lichen, Pemphigus, Pruritus, Psoriasis, Skin

Treating chronic pain with low dose naltrexone and ultralow dose naltrexone: a review paper

Condition: Pain

Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder (MDD): A Double Blinded Randomized Controlled Pilot Study

Condition: Depression

Variable response to low-dose naltrexone in patients with Darier disease: a case series

Condition: Darier, Hailey Hailey, Hailey-Hailey, Skin

Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study

Condition: Arthritis, Autoimmune, Medications, Pain, RA, Rheumatoid, Rheumatoid arthritis

Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis

Condition: Psoriasis, Skin

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

Condition: Alcohol, General, Medications

Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A)

Condition: Charcot Marie Tooth, Charcot-Marie-Tooth, Neuropathy

The Use of Low-Dose Naltrexone for Chronic Pain

Condition: Pain

Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis

Condition: Psoriasis, Skin

The Uses of Naltrexone in Dermatological Conditions

Condition: Hailey Hailey, Hailey-Hailey, Lichen, Pruritus, Psoriasis, Scleroderma, Skin

Intermittent blockade of OGFr and treatment of autoimmune disorders

Condition: Autoimmune, Fatigue, Fibromyalgia, MS, Multiple Sclerosis

Clinical utility of the cold pressor test: evaluation of pain patients, treatment of opioid-induced hyperalgesia and fibromyalgia with low dose naltrexone

Condition: Fibromyalgia, Opiod, Pain

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review

Condition: Dermatitis, Hailey Hailey, Hailey-Hailey, Lichen, Pruritus, Skin

The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma

Condition: Breast, Cancer

Treatment of psoriasis vulgaris using low-dose naltrexone

Condition: Psoriasis, Skin

Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization

Condition: Alcohol, Cancer, Complex Regional Pain Syndrome, Crohn’s, CRPS, Fibromyalgia, Hailey Hailey, Hailey-Hailey, IBD, IBS, Inflammatory Bowel Disease, Irritable Bowel Syndrome, MS, Multiple Sclerosis, Opiod, Pain, Substance Use