Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Sjogren's Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports (Abstract)
Treating chronic pain with low dose naltrexone and ultralow dose naltrexone: a review paper (Abstract)
Plasma beta-endorphin levels, naltrexone, and haloperidol in autistic children (Abstract)
Psychopharmacology of aggression in children and adolescents with autism... (Abstract)
Use of low dose naltrexone and change in use of prescription drugs in patients with inflammatory bowel disease... (Abstract)
Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer (Abstract)
Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis.,, (Abstract)
Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking... (Abstract)
Low Dose Naltrexone in the Treatment of Crohn's Disease: A Case Series (Abstract)
Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome... (Abstract)
Human herpesvirus-6 viral load and antibody titer in serum samples of patients with multiple sclerosis (Abstract)
Association of low-dose naltrexone and transcranial direct current stimulation in fibromyalgia... (Abstract)
Ocular surface itch and pain: key differences and similarities between the two sensations (Abstract)
Therapeutic options for the treatment of post-acute sequelae of COVID-19: a scoping review
Naltrexone Accelerates Full‐Thickness Cutaneous Wound Healing by Enhancing Remodeling (Abstract)
Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia (Abstract)
Neuroimmunotherapy of untreatable metastatic solid tumors with subcutaneous low-dose interleukin-2... (Abstract)
Novel and emerging treatments for autism spectrum disorders: a systematic review (Abstract)
Low-dose naltrexone and opioid consumption: a drug utilization cohort study... (Abstract)
Dose Escalation of Naltrexone to Reduce Stress Responses Associated With Opioid Antagonist Induction... (Abstract)
Clinical utility of the cold pressor test: evaluation of pain patients... (Abstract)
Co-Administration of Low-Dose Naltrexone and Bupropion Reduces Alcohol Drinking... (Abstract)
Long-term remission of adenoid cystic tongue carcinoma with low dose naltrexone... (Abstract)
Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome (Abstract)
Relationship of human herpes virus 6 and multiple sclerosis: A systematic review and meta-analysis (Abstract)
Ultra-low dose naloxone restores the antinocicepitve effect of morphine in... (Abstract)
Combination therapy: A New Tool for the Management of Obesity (Abstract)
LDN and Pain Paper
Low dose naltrexone in the treatment of dissociative symptoms (Abstract)
Bernard Bihari, MD: Low-Dose Naltrexone for normalizing immune system function (Abstract)
Modulation of the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis... (Abstract)
Naltrexone in young autistic children: replication study and learning measures (Abstract)
Functional modulation on macrophage by low dose naltrexone (LDN) (Abstract)
Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders (Abstract)
Intermittent blockade of OGFr and treatment of autoimmune disorders (Abstract)
Combination therapy for obesity (Abstract)
Low dose naltrexone in therapy resistant IBD, a case series (Abstract)
Low Dose Naltrexone in Endometrial Intraepithelial Neoplasia (Abstract)
The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction ... (Abstract)
A Comprehensive Review: Chronic Pain Sequelae in the Presence of Ehlers-Danlos Syndrome (Abstract)
Low-dose naltrexone use for the management of post-acute sequelae of COVID-19 (Abstract)
Tracking the spread of Parkinson’s proteins from gut to brain
Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series (Abstract)
Naltrexone Hydrochloride 1.5-mg and 4.5-mg Capsules (Abstract)
Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin (Abstract)
Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19 (Study)
Low-Dose Naltrexone: A New Therapy Option for Complex Regional Pain Syndrome Type I Patients (Abstract)
Anxiolytics, adrenergic agents, and naltrexone (Abstract)
Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Condition... (Abstract)
Low dose naltrexone in multiple sclerosis: Effects on medication use... (Abstract)
Opioid growth factor (OGF) for hepatoblastoma: a novel non-toxic treatment (Abstract)
Immunometabolic Modulatory Role of Naltrexone in BV-2 Microglia Cells (Abstract)
Geo-Statistical Analysis of Possible Spirochetal Involvement in Multiple Sclerosis (Abstract)
Off-label pharmacological treatment for neuropathic pain... (Abstract)
Treatment of dissociative symptoms with opioid antagonists: a systematic review (Abstract)
Effects of Naloxone and Naltrexone on Locomotor Activity in C57BL/6 and DBA/2 Mice (Abstract)
[Met 5]-enkephalin preserves diffusion metrics in EAE mice (Abstract)
Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex (Abstract)
129 Medication Assisted Treatment Protocol (Abstract)
Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers (Abstract)
In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis (Abstract)
Opioid growth factor and low dose naltrexone impair central nervous system infiltration... (Abstract)
Long-term effects of naltrexone on self-injurious behavior (Abstract)
Treatment of psoriasis vulgaris using low-dose naltrexone (Abstract)
Low-dose naltrexone: a novel treatment for Hailey-Hailey disease (Abstract)
Immunological changes in IBD patients responding to low-dose naltrexone treatment (Abstract)
Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome... (Abstract)
The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice (Abstract)
Long COVID: major findings, mechanisms and recommendations (Abstract)
Low-Dose Naltrexone Improves post-COVID-19 Condition Symptoms
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study (Abstract)
Low-dose Naltrexone as a Treatment for Chronic Fatigue Syndrome (Abstract)
Erythromelalgia in a Patient with Mast Cell Activation Syndrome: Response to Low Dose Naltrexone (Abstract)
Naltrexone in autistic children: a double-blind and placebo-controlled study (Abstract)
A randomised, controlled trial of low dose naltrexone for the treatment of opioid dependence (Abstract)
Effects of low-dose naltrexone on feed intake, growth, endocrine and immune... (Abstract)
Early outcomes following low dose naltrexone enhancement of opioid detoxification (Abstract)
The Long Term Suppression of Experimental Autoimmune Encephalomyelitis... (Abstract)
Naltrexone modulates growth in infant rats )Abstract)
Impact of Low Dose Naltrexone (LDN) on antiretroviral therapy (ART) treated HIV+ adults... (Abstract)
A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot-Marie-Tooth type 1A (Abstract) (LDN, low dose naltrexone)
Topical Therapeutic Options in Corneal Neuropathic Pain (Abstract)
Diagnosis and Management of a Hypersensitivity Reaction to Titanium-Containing Surgical Clips... (Abstract)
Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19
Naltrexone a potential therapeutic candidate for COVID-19 (Abstract)
Low Dose Naltrexone in the Treatment of HIV Infection (Abstract)
Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes... (Abstract)
Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study (Abstract)
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone (Abstract)
Treatment of clinically isolated syndrome with Low Dose Naltrexone (Abstract)
Low-Dose Naltrexone in Diseases' Treatment: Global Review (Abstract)
Low Dose Naltrexone and Lung Cancer: A Case Report and Discussion (Abstract)
Opioid antagonist-induced regulation of organ development (Abstract)
The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer ... (Abstract)
Low-dose naltrexone (LDN)—review of therapeutic utilization (Abstract)
Response to: Invasive Treatments for Low Back Disorders and the ACOEM Practice Guidelines (Abstract)
An Update on the Uses of Naltrexone in Clinical Practice (Abstract)
Current pharmacotherapeutic properties of low-dose naltrexone therapy in humans and possible therapeutic and prophylactic indications in cats and dogs
Low-dose naltreoxone for the treatment of irritable bowel syndrome: a pilot study (Abstract)
The opioid antagonist naltrexone improves murine inflammatory bowel disease (Abstract)